Beilstein J. Org. Chem.2014,10, 1808–1816, doi:10.3762/bjoc.10.190
3Y1 rat fibroblasts. Concern about potential foodintoxication caused by accidental massive ingestion of A. sacrum was dispelled by the absence of 1 in commercial products. A manual procedure for degrading 1 in raw colonies was also developed, enabling a convenient on-site detoxification at
restaurants or for personal consumption.
Keywords: Aphanothece sacrum; cyanobacterium; foodintoxication; natural products; sacrolide A; suizenji-nori; Introduction
Cyanobacteria continue to be core sources for bioactive secondary metabolites [1][2], and their significance in drug discovery has increased
cytotoxicity of 1 raised concerns about potential foodintoxication. To evaluate the presence of 1 in these products, extracts were prepared and examined by antifungal testing and LC–MS analysis. The products were softened or desalted by soaking in water and then subjected to the same extraction and